General Cell Based Assays
Ubpbio Proteasome Activity Fluorometric Assay Kit II
Proteasome Activity Fluorometric Assay Kit II can be used for assaying the constitutive proteasomes' chymotrypsin-like, trypsin-like and caspase-like activities in vitro using purified proteasome, cell lysates or tissue extracts. The proteasome cleaves the supplied fluorogenic substrates, and the released AMC fluorescence can be monitored using a plate reader or fluorometer at the excitation/emission wavelength of 360nm/460nm, respectively.
American Research Products Inc Rat myeloperoXidase antineutro
Rat myeloperoXidase-antineutrophil cytoplasmic antibody (MPO-ANCA) ELISA kit from CUSABIO Detection Range 0 625 U/mL-40 U/mL Sensitivity 0 156 U/mL Sample serum plasma Method Sandwich
Apexbio Technology LLC DiscoveryProbe™ PI3K/Akt/mTOR Compound Library 100uL/well(10 mM solution),96 Well Deep Well Plate
The DiscoveryProbe PI3K/Akt/mTOR Compound Library comprises 178 small molecule inhibitors targeting PI3K/Akt/mTOR-related signaling pathways This pathway regulates processes such as cell growth proliferation survival apoptosis and metabolism in various cell types making it a frequent focus for oncology and disease mechanism research The collection encompasses compounds approved by regulatory agencies including FDA and EMA and agents studied extensively in academic and pharmaceutical research settings Representative inhibitors within this library include PI3K-selective inhibitors ATM/ATR inhibitors (DNA damage response regulators) and DNA-PK and GSK-3 targeting compounds providing comprehensive coverage for biological pathway elucidation drug discovery screening and pharmacological mechanism-of-action studies
Cayman Chemical Protein Carbonyl Colorimetric
Cayman’s Protein Carbonyl Colorimetric Assay Kit utilizes the DNPH reaction to measure the protein carbonyl content in plasma, serum, cell lysates, or tissue homogenates in a convenient 96-well format. The amount of protein-hydrazone produced is quantified spectrophotometrically at an absorbance between360-385 nm. The carbonyl content can then be standardized to the protein concentration.
Abcam Metformin hydrochloride (mM/ml), AMPK activator, 100MM_ML
MW 165.63 g/mol, Purity >99%. AMPK activator. Antidiabetic and anticancer activity in vivo. Rapidly crosses the blood-brain barrier.
The product is subject to the following: Abcam Restricted Use Statement
Arbor Assays Glutathione Fluorescent Detection Kit (1 Plate)
The DetectX Glutathione (GSH) Fluorescent Detection Kit utilizes a proprietary non-fluorescent molecule, ThioStar, that covalently binds to the free thiol group on GSH to yield a highly fluorescent product.
Abcam RG 108, non-nucleoside DNA methyltransferase inhibitor (DNMT), 10MG
MW 334.3 Da, Purity >99%. Novel, non-nucleoside DNA methyltransferase (DNMT) inhibitor, capable of interacting with the DNMT1 active site (IC₅₀ = 115 nM). Inhibits DNA methylation in human cancer cell lines. Reactivates several epigenetically silenced tumour suppressor genes in vitro. Capable of enhancing the efficiency of induced pluripotent stem cell (iPS) generation.
The product is subject to the following: Abcam Restricted Use Statement
Meso Scale Discovery R-PLEX Human AXL/UFO ASY
The R-PLEX Human AXL UFO Assay from Meso Scale Diagnostics is a multiplex immunoassay kit that allows for the simultaneous quantitative measurement of AXL in human serum plasma and cell culture supernatants It utilizes Meso Scale Diagnostics electrochemiluminescent detection technology and provides high sensitivity up to 5 logs of dynamic range and low sample volume requirements This assay kit includes a 96-well plate coated with capture antibody detection antibody read buffer wash buffer calibrator diluent and lyophilized calibrator It can test up to 80 samples in duplicate and has a testing time of 3 5 hours
Cytoskeleton, Inc. G ACTIN F ACTIN ASSAY KIT
G-Actin/F-actin In Vivo Assay Biochem Kit - Cytoskeleton, Inc.
Cayman Chemical a-D-Glucose-1-phosphatesodI 1g
An intermediate in glycogen metabolism; precursor in the biosynthesis of UDP-glucose; can be formed during glycogen breakdown via phosphorolytic cleavage of glycogen by glycogen phosphorylase; can be converted to glucose-6-phosphate by phosphoglucomutase; is combined with CTP to form CDP-glucose in S. typhi
Eurofins Discoverx PathHunter eXpress GPR12 CHO-K1 β-Arrestin Orphan GPCR Assay, 2-Plate Kit. (93-0329E2ACP1M)
The PathHunter GPR12 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR12 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR12 and EA-tagged β-Arrestin-2. Activation of GPR12 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpressNR CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0323E2CP0L)
The PathHunter MLNR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. motilin) based activation of MLNR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged MLNR and EA-tagged β-Arrestin-2. Activation of MLNR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress TBXA2R U2OS β-Arrestin GPCR Assay, 10-Plate Kit. (93-0322E3CP5L)
The PathHunter TBXA2R eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. thromboxane A2, prostaglandins) based activation of TBXA2R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged TBXA2R and EA-tagged β-Arrestin-2. Activation of TBXA2R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress F2RL3 (PAR4) CHO-K1 β-Arrestin GPCR Assay, 2pl Kit. (93-0279E2CP0M)
The PathHunter F2RL3 (PAR4) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. serine proteases) based activation of F2RL3 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged F2RL3 and EA-tagged β-Arrestin-2. Activation of F2RL3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.